The immune system is implicated in a variety of diseases: Immune system dysregulation can result in a host of pathologies: e.g., cancer, autoimmunity and diseases associated with chronic inflammation, such as atherosclerosis and diabetes.
The microbiota constitutively inhabits all barrier surfaces and thus can affect the response to infections, the development of metabolic, neurological, autoimmune and inflammatory diseases, as well as the incidence, progression and treatment of cancer.
Integrative, systems immunology approaches are required:
Our understanding of human health and the development of new preventive and therapeutic approaches requires the comprehensive evaluation of the whole human metaorganism (microbes and host immune states), data-driven computational modeling and analysis to develop predictive models and generate and test new hypotheses.
Large-scale human studies: Capacity and expertise to design and execute human studies involving large-scale immune and microbiome monitoring coupled with intensive computational analysis and modeling;
Scientific expertise: Intellectual leadership and training for microbiome and systems human immunology and associated profiling technologies, including the development and hosting of novel computational immunology approaches and tools;
Empowering the community via technology: Fee-for-service access to advanced immune monitoring technologies and associated services typically not available in individual labs.